Loratadine (Clarityn) vs Cetirizene (Piriteze, Zirtek) tablets What is the difference? Loratadine and Cetirizene are the two most common over-the counter treatments for allergies producing very similar results. They are both known as anti-histamines. They work by calming the bodys immune system to allergens. Some people react better to one type of medicine than the other (we sell them both) so we cannot suggest which is better so would simply state that you try them both and see what works best for you.
