E45 Itch Relief Cream 50 g – Anti Itch Cream for Skin Irritation – Non-Greasy E45 Cream to Relieve Itching – Eczema Dermatitis Cream – Instantly Soothes and Calms Skin - E45 for Itching. ANTI-ITCHING – E45 Itch Relief Cream contains an anti-itch ingredient, Lauromacrogols, which act as a topical anaesthetic and soothes the itch caused by eczema, dermatitis, pruritus and other dry skin conditions.